Computational Fluid Dynamics On Biomedical Field

ABSTRACT

Computational fluid dynamics, usually abbreviated as CFD, is a branch of fluid mechanics that uses numerical methods and algorithms to solve and analyze problems that involve fluid flows. The human body fluid has complex behavior and its study is very difficult. Experiments to understand the fluid behavior might be time consuming and costly. CFD complement experimental and analytical approaches by providing an alternative cost-effective means of simulating real fluid flow, particularly in human body fluids. CFD has the capacity to simulate flow conditions that are not reproducible during experimental tests found in geophysical and biological fluid dynamics, such as scenarios that are too huge, too remote, or too small to be simulated experimentally.

This report discusses about the components of CFD and its application in various bio- medical field. All CFD processes contain three main components to provide useful information, such as pre-processing (pre-processor), solving mathematical equations (solver), and post-processing (post processor). Initial accurate geometric modeling and boundary conditions are essential to achieve adequate results. Medical imaging, such as ultrasound imaging, computed tomography, and magnetic resonance imaging can be used for modeling, and Doppler ultrasound, pressure wire, and non-invasive pressure measurements are used for flow velocity and pressure as a boundary condition.

Many simulations and clinical results have been used to study congenital heart disease, heart failure, ventricle function, aortic disease, work of heart, coronary artery disease and carotid and intra-cranial cardiovascular diseases. With decreasing hardware costs and rapid computing times, researchers and medical scientists may increasingly use this reliable CFD tool to deliver accurate results. A realistic, multidisciplinary approach is essential to accomplish these tasks. Indefinite collaborations between mechanical engineers and clinical and medical scientists are essential.

 1.INTRODUCTION

The aim of this report is to survey the state of CFD technology in the biomedical field and discuss the development and current scenario of CFD tool in the biomedical field. Approximately 80% of the human body mass consists of water. The vascular system (arteries and veins) delivers nutrients and retrieves waste products. The respiratory system delivers oxygen and retrieves carbon dioxide. These vital transport systems are mainly tubular in nature, and are powered by the heart and lung respectively. Any kind of damage or obstruction of these transport systems will, in all likelihood, result in a variety of diseases than can have a profound effect on wellness and quality of life. Vessel damage or obstruction may be treated by a variety of surgical and interventional procedures: stenting, balloon angioplasty, in situ drug delivery for unclotting, bypass surgery, artificial organ implantation, etc. Many of these procedures are performed daily on thousands of patients, and have led to an impressive empirical knowledge database. Some of these procedures have statistically significant failure rates, indicating a need to study in depth the aid dynamics before and after the intervention. As in the manufacturing industries, it would be highly desirable to predict the outcome of an intervention before 'cutting tissue', particularly for complex cases where a detailed empirical database is lacking.

The basic steps required for any type of flow simulation are the following:

Ø Pre-Processing or Problem Definition:

Ø Geometry (Surface);

Ø Boundary and Initial Conditions;

Ø Grid Generation;

Ø Fluid-Structure Solver; and

Ø Visualization and Data Reduction.

Any type of interventional simulation will require accurate modeling of patient-specific anatomy and physiologic conditions. It is here where the biggest obstacle to routine simulations lies. Typically, only the anatomy is imaged. Flows may be measured non-invasively by PCMRA or ultrasound (US). However, the accuracy for these measurements can be problematic due to imaging artifacts and noise. The compliance of an arterial wall is difficult to obtain, and its pressure/dilatation may be highly nonlinear.

Nevertheless, recent advances in:

Ø Radiology (high contrast imaging);

Ø Image-to-surface definition tools;

Ø Automatic grid generation;

Ø Fast in compressible flow solvers and realistic boundary conditions;

Ø Fluid-structure interaction techniques;

Ø Insightful visualization;

Ø Validation in the form of in vitro/vivo studies; and

Ø Increased compute and graphics power have led to a favorable confluence of techniques that have made predictions on the living human being possible, and in some cases, routinely so.

In the sequel, we focus on recent advances, outstanding issues and obstacles for each one of these areas. Thereafter, we show several examples to demonstrate that what a vision was several years ago is maturing rapidly and may indeed lead to medical tools in the near future.

2. DESCRIPTION

2.1 What is CFD

Computational fluid dynamics (CFD) is a mechanical engineering field for analyzing fluid flow, heat transfer, and associated phenomena, using computer-based simulation. CFD is a widely adopted methodology for solving complex problems in many modern engineering fields. The merit of CFD is developing new and improved devices and system designs, and optimization is conducted on existing equipment through computational simulations, resulting in enhanced efficiency and lower operating costs.

The technique is very powerful and spans a wide range of areas. In the beginning, CFD was primarily limited to high-technology engineering areas-, but now it is a widely adopted methodology for solving complex problems in many modern engineering fields. CFD is becoming a vital component in the design of industrial products and systems. Examples are aerodynamics and hydrodynamics of vehicles, power plants including turbines, electronic engineering, chemical engineering, external and internal environmental architectural design, marine and environmental engineering, hydrology, meteorology, and bio-medical engineering.

The study of fluid mechanics includes the study of fluids either in motion (fluid in dynamic mode) or at rest (fluid in stationary mode). CFD is usually dedicated to fluids that are in motion, and how the fluid flow behavior influences processes. Additionally, the physical characteristics of fluid motion can usually be described through fundamental mathematical equations, usually in partial differential form, which govern the process of interest and are often called governing equations. These mathematical equations are solved by being converted by computer scientists using high-level computer programming languages. The computations reflect the study of fluid flow through numerical simulations, which involves employing programs performed on high-speed digital computers to attain numerical solutions.

2.2 Component of computational fluid dynamics

Computational fluid dynamics is usually performed with use of commercial CFD codes. CFD codes are structured by numerical algorithms that consider fluid-flow problems. All CFD codes must contain three main components to provide useful information; 1) a pre-processor, 2) a solver, and 3) a post-processor.

2.2.1 Pre-processor

Pre-processing consists of inputting a fluid flow problem into a CFD program. This includes defining the geometry of the region of interest, grid or mesh generation, selection of the physical and chemical phenomena that need to be modeled, a definition of fluid properties, and specification of appropriate boundary conditions at the inlet and outlet. The larger the number of cell grids the better the solution accuracy. The accuracy of a solution and the required time for computational problem solving are dependent on grid fineness. Most of the time spent is devoted to this process.

In cardiovascular systems, computational imaging tools may confer the grid generation information, but limitations are that the resolution of current imaging tools is still low and geometry varies according to the cardiac cycle. Blood acts as a non-Newtonian fluid, because blood has varying viscosity according to its shear rate. Fig -shows the correlation between blood viscosity and shear rate.Thus, the correct viscosity model using a mathematical equation should be selected according to the range of shear rates. The energy conservation law of fluid motion is an important consideration for basic concepts. Boundary conditions, such as blood pressure, blood flow velocity, and temperature are readily available from invasive and non-invasive measurements based on the region of interest. Another essential consideration is that these boundary conditions also vary according to the cardiac cycle and the unique conditions of coronary circulation.  Fig- 2 shows a sample of these pressure and velocity profiles during cardiac cycles for modeling and CFD.

 2.2.2 Solver

Numerical solution techniques are available such as finite difference, finite element, finite volume, and spectral methods. Each has a distinct numerical technique, but the basis of the solver is to perform an approximation of unknown flow variables by means of simple functions, discretionary by substitution of the approximations into the governing flow, and an algebraic solution. If the user uses a solution technique, the time spent depends upon the calculating capacity of the computer. Usually, the finite volume method is adopted for cardiovascular systems.

2.2.3 Post-processor

The object of this process is to visualize the computational results. Many visualization tools have been developed, including domain geometry and grid display, vector plots, line and shaded contour plots, two-dimensional and three-dimensional surface plots, particle tracking, and color postscript outputs. After this process, the researcher can easily understand the simulation results. For example, the changes in blood flow profiles, pressure distribution, wall shear stress (WSS), oscillating shear index (OSI), and shear rate can be visualized using color rendering techniques. Furthermore, a cyclic motion view can be obtained during cardiac cycles.

 2.3 Application of CFD in Biomedical field( Cardiovascular system)

In the biomedical field, CFD is still emerging. The main reason why CFD in the biomedical field has lagged behind is the tremendous complexity of human body fluid behavior. Recently, CFD biomedical research is more accessible, because high performance hardware and software are easily available with advances in computer science.

 All CFD processes contain three main components to provide useful information, such as pre-processing, solving mathematical equations, and post-processing. Initial accurate geometric modeling and boundary conditions are essential to achieve adequate results. Medical imaging, such as ultrasound imaging, computed tomography, and magnetic resonance imaging can be used for modeling, and Doppler ultrasound, pressure wire, and non-invasive pressure measurements are used for flow velocity and pressure as a boundary condition.

Many simulations and clinical results have been used to study congenital heart disease, heart failure, ventricle function, aortic disease, and carotid and intra-cranial cerebrovascular diseases. With decreasing hardware costs and rapid computing times, researchers and medical scientists may increasingly use this reliable CFD tool to deliver accurate results. A realistic, multidisciplinary approach is essential to accomplish these tasks. Indefinite collaborations between mechanical engineers and clinical and medical scientists are essential.

CFD may be an important methodology to understand the pathophysiology of the development and progression of disease and for establishing and creating treatment modalities in the cardiovascular field.

Recently, medical researchers have used simulation tools to assist in predicting the behavior of circulatory blood flow inside the human body. Computational simulations provide invaluable information that is extremely difficult to obtain experimentally and is one of the many CFD sample applications in the biomedical area in which blood flow through an abnormal artery can be predicted. CFD analysis is increasingly performed to study fluid phenomena inside the human vascular system. Medical simulations of circulatory function offer many benefits. They can lower the chances of postoperative complications, assist in developing better surgical procedures, and deliver a good understanding of biological processes, as well as more efficient and less destructive medical equipment such as blood pumps. Furthermore, medical applications using CFD have expanded not only into the diseased clinical situation, but also into health life supportives, such as sport medicine and rehabilitation. Several examples are discussed as follows.

 2.3.1 Coronary artery disease; atherosclerosis

Although many systemic risk factors predispose development of atherosclerosis, it preferentially affects certain regions of circulation, suggesting developing coronary atherosclerosis.

Information regarding the spatial distribution of intraluminal hemodynamics of the coronary that lesion-prone areas may at least in part be due to biomechanically related factors. Furthermore, luminal hemodynamics, such as flow velocity, pressure changes, and WSS have been suggested as other risk factors for vascular tree are available using CFD.

Fig-3 shows an example of performing CFD from pre-processing to post-processing. At first, a mesh or grid of region of interest is generated from the coronary extract images of computerized tomogram. The researchers might use any three dimensional medical images. The Digital Imaging and Communications in Medicine (DICOM) files should be converted into a file which can be used in a soft ware analyzing three dimensional vector information. All the digitalized data, such as velocity and pressure information according as cardiac cycle as a boundary condition were selected to put into an appropriate algebraic solution. And, the next step is mathematic solving process by the computer. At this process, mechanical engineers and medical scientists should discuss about all the clinical situations for selecting an appropriate viscosity models due to non-Newtonian fluid analysis, governing equations. Final step is visualization process for user. There are so many representative processing results, such as pressure profiles, velocity profiles, particle tracing, time-averaged wall shear stress (TAWSS), OSI, etc. This figure shows high TAWSS, OSI at bifurcation. TAWSS shows higher at bifurcation apex, but OSI shows higher at lateral side of side branch.

 2.3.1 Congenital heart disease; Fontan Circulation

Fontan circulation, first described by Fontan and Baudet, is characterized by the absence of a right ventricle and functions under unique hemodynamics. The key targets of geometric correction of Fontan procedure are the separation of systemic and pulmonary venous return and establishing the pathway of a passive, direct, and unobstructed connection between the systemic venous return and the pulmonary artery (PA) for treating single ventricle physiology, as one example of congenital heart disease.

While the Fontan procedure is a classic treatment procedure for a functional single ventricle in patients with congenital heart diseases, it has a potentially harmful effect for normal circulation. The absence of a right ventricle induces a pressure elevation in the venous system. The basic pathophysiological mechanisms originate from increased central venous pressure and the superior vena cava (SVC) and inferior vena cava (IVC).

Elevated central venous pressure is poorly tolerated over time, particularly in the IVC, and has deleterious effects on liver and splanchnic circulation. Protein-losing enteropathy and plastic bronchitis characterize the worst outcomes. At the liver level, elevated central venous pressure may induce complex liver dysfunction and stimulate angiogenesis factors favoring a venovenous anastomosis, pulmonary venous fistula, and, potentially, aortopulmonary collateral anastomoses. At the lung level, the upper PA branches are poorly or not perfused, and the lymphatic circulation is globally impaired. The single ventricle faces a significant increase in total systemic resistance because it needs to "push" against not only the usual systemic resistance but also lung resistance. As a consequence, the systemic ventricle becomes hypertrophied, with elevated end-diastolic pressure, which diminishes diastolic performance.Several studies have focused on solving these problems.

Computational fluid dynamics was performed after artificially modeling the Fontan circulation using medical information. Fig-5  shows the velocity profiles at maximal flow among cardiac cycle time periods. Significantly increased flows were driven from the SVC, particularly during inspiration, indicating that unmixed blood flow to the PA and blood flow in the IVC may be more congested during inspiration than during expiration. During standing and inspiration, blood flow profiles aggravate the stagnation of systemic venous blood flow return and failure of the blood mixing function, suggesting that an artificial pumping device is essential for correcting Fontan circulation failure.

 2.3.2 Work of a Heart

This is another example of using CFD as a diagnostic tool for evaluating heart function. Work of the heart (WHO) is calculated using a pressure-volume curve. Some new indirect diagnostic tools are available to evaluate the WOH. The modified Windkessel model was used with blood viscosity models to develop a mathematical model for estimating WOH utilizing the pulse waves between two points of a vessel. The human arterial system is a network of vessels that converts intermittent flow of the heart into steady flow through the capillaries and venous system. The modified Windkessel model is a type of lumped parameter model that allows simulation of blood flow in the entire circulatory system as an electrical circuit (Fig-6).

In this figure, Qin, Q1, and Q1 are defined as the flow rate exiting from the left ventricle during systole, the flow rate passing through the peripheral system, and the flow rate passing through the distal system, respectively. Similarly, p1 and p2 are the pressures measured at the proximal and distal locations, representatives of central and peripheral blood pressure, respectively. Moreover, C1 and C2 are proximal and distal compliances, where L corresponds to the inertia of blood (L=0.017 mmHgs²/mL). Flow rate in the left ventricle can be calculated with the mathematical fluid analysis shown in  Fig-7 by measuring blood pressure curves at two points in the peripheral arteries (brachial and radial arteries).

The blood viscosity model is essential to solve the problem of an increased burden of work on the heart, so further study will be needed to verify which viscosity model results are similar compared to in vivo results. However, this type of study might suggest the possibility of developing non-invasive devices for measuring WHO. Fig-7

Proximal (Q1) and distal (Q2) flow rates in the left ventricle calculated with the Herschel-Bulkley equation.

2.3.4 Others cardiovascular systems

CFD is being increasingly employed to understand carotid stenosis and its biological properties according to geometric risks, or via virtual prototyping to Physiology and diseases of the aorta, carotid, and cerebral arteries are also studied with recommend the best design for surgical reconstruction during a carotid endarterectomy, and conjunctional research magnetic resonance images. Furthermore, CFD is being used to better understand blood flow through an aneurysm in the abdominal artery, and the development and progression of aortic dissection.

3.     Advantages and Limitations

There are many advantages when considering CFD. Theoretical development in the computational sciences focuses on the construction and solution of governing equations and the study of various approximations to these equations. CFD complements experimental and analytical approaches by providing an alternative cost-effective means of simulating real fluid flow, particularly in human body fluids. CFD has the capacity to simulate flow conditions that are not reproducible during experimental tests found in geophysical and biological fluid dynamics, such as scenarios that are too huge, too remote, or too small to be simulated experimentally. Furthermore, CFD provides rather detailed visual and comprehensive information when compared to analytical and experimental fluid dynamics.

Although CFD is advantageous, it cannot easily replace experimental testing as a method to gather information for design purposes. Despite its many advantages, the researcher must consider the inherent limitations of applying CFD. Numerical errors occur during computations; therefore, there will be differences between the computed results and reality. Visualizing numerical solutions using vectors, contours, or animated movies of unsteady flow are the most effective ways to interpret the huge amount of data generated from numerical calculations. Wonderfully bright color pictures may provide a sense of realism to the actual fluid mechanics inside a flow system, but they are worthless if they are not quantitatively correct. Thus, numerical results must always be thoroughly examined before they are believed; therefore, a CFD user needs to learn how to properly analyze and make critical judgments about the computed results.

Another important comment is collaboration between mechanical engineers and medical scientists. Not any one department can deliver a result. Each discipline should provide feedback on the results at each step.

4.     Conclusions

This report has identified current four applications of CFD in Biomedical field. Rapid advances of many industrial applications in computer science are outstanding, which requires changes in CFD. This changing situation is partly attributed to the rapid evolution of CFD techniques and models. Excellent creative models for simulating complex fluid mechanics problems in the human body and therapeutic models are now being progressively applied, particularly with the availability of commercial CFD computer programs. The increasing use of these programs in medicine might reveal how demanding the practical problems analyzed by CFD are. With decreasing hardware costs and rapid computing times, researchers and medical scientists may be relying increasingly on this reliable CFD tool to deliver accurate results. However, a realistic multidisciplinary approach is essential to accomplish these tasks. Indefinite collaborations between mechanical engineers and clinical and medical scientists are essential. CFD may be an important methodology for understanding the pathophysiology of developing and progressing cardiovascular disease and for establishing creative treatment moralities in the cardiovascular field.

With regards,
Rabin